Sensory gating is related to positive and disorganised schizotypy in contrast to smooth pursuit eye movements and latent inhibition

Hills, P.J, Vasilev, M.R, Ford, P, Snell, L, Whitworth, E, Parsons, T, Morisson, R, Silveira, A and Angele, B (2021) 'Sensory gating is related to positive and disorganised schizotypy in contrast to smooth pursuit eye movements and latent inhibition.' Neuropsychologia, 161. e107989.

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Abstract

Since the characteristics and symptoms of both schizophrenia and schizotypy are manifested heterogeneously, it is possible that different endophenotypes and neurophysiological measures (sensory gating and smooth pursuit eye movement errors) represent different clusters of symptoms. Participants (N = 205) underwent a standard conditioned-pairing paradigm to establish their sensory gating ratio, a smooth-pursuit eye-movement task, a latent inhibition task, and completed the Schizotypal Personality Questionnaire. A Multidimensional Scaling analysis revealed that sensory gating was related to positive and disorganised dimensions of schizotypy. Latent inhibition and prepulse inhibition were not related to any dimension of schizotypy. Smooth pursuit eye movement error was unrelated to sensory gating and latent inhibition, but was related to negative dimensions of schizotypy. Our findings suggest that the symptom clusters associated with two main endophenotypes are largely independent. To fully understand symptomology and outcomes of schizotypal traits, the different subtypes of schizotypy (and potentially, schizophrenia) ought to be considered separately rather than together.

Item Type:	Article
UN SDGs:	Goal 3: Good Health and Well-Being
Keywords:	schizophrenia, schizotypy, schizotypal personality, latent inhibition, smooth pursuit eye movements, sensory gating, endophenotypes
Divisions:	School of Sciences
Date Deposited:	08 Aug 2023 17:49
Last Modified:	23 Aug 2024 14:53
ISSN:	0028-3932
URI / Page ID:	https://researchspace.bathspa.ac.uk/id/eprint/15645

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