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Ipsilateral cortical motor desynchronisation is reduced in benign epilepsy with centro-temporal spikes

Brindley, L.M, Koelewijn, L, Kirby, A, Williams, N, Thomas, M, te Water-Naudé, J, Gibbon, F, Muthukumaraswamy, S, Singh, K.D and Hamandi, K (2016) 'Ipsilateral cortical motor desynchronisation is reduced in benign epilepsy with centro-temporal spikes.' Clinical Neurophysiology, 127 (2). pp. 1147-1156. ISSN 1388-2457

Abstract

Objective:- Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). Methods:- Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. Results:- In children with BECTS, manual dexterity was below the population mean (p = .002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group (p = .03) and predicted by epileptic seizure recency (p = .02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity(p = .04). Conclusions:- Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures. Significance:- These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.

Item Type: Article
Additional Information:

First published online on 10 October 2015 ahead of its inclusion in an issue.

Keywords: development; BECTS; MEG; movement; oscillations
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: College of Liberal Arts
Date Deposited: 21 Nov 2016 16:20
Last Modified: 12 Dec 2016 11:11
URI: http://researchspace.bathspa.ac.uk/id/eprint/8392
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