Polio vaccination and Chronic Fatigue Syndrome

Smith, A.P and Thomas, M (2021) 'Polio vaccination and Chronic Fatigue Syndrome.' Asian Journal of Research in Infectious Diseases, 8 (4). pp. 43-49. ISSN 2582-3221

14461.pdf - Published Version
CC BY 4.0.

Download (277kB) | Preview
Official URL: https://doi.org/10.9734/AJRID/2021/v8i430248


Background:- Previous research has suggested that enteroviruses may be implicated in the development and persistence of Chronic Fatigue Syndrome (CFS). One method of investigating this topic has been to use a polio vaccination challenge, and a previous study showed that CFS patients had more shedding than healthy controls. There was no effect of the vaccination on the clinical condition or wellbeing of the CFS patients. Methods:- In the previous study, the control group were more likely to have had a recent booster vaccination. This was controlled in the present study, where 18 CFS patients were randomly assigned to vaccination or placebo conditions. Nine healthy volunteers were also given the polio vaccination. Results:- The results confirmed that vaccination had no negative effects on the CFS group. Although there was more virus shedding in the CFS polio group than in the control polio group, this difference was not significant. Conclusion:- This study confirms that polio vaccination is not contraindicated in CFS patients but could not confirm that they are more susceptible to enterovirus infection.

Item Type: Article
Keywords: Chronic Fatigue Syndrome (CFS), polio vaccination, enteroviruses, wellbeing, cognition
Divisions: School of Sciences
Research Centres and Groups: Psychology Research Centre for Health and Cognition
Identification Number: https://doi.org/10.9734/AJRID/2021/v8i430248
Date Deposited: 20 Dec 2021 17:59
Last Modified: 17 May 2022 16:09
URI / Page ID: https://researchspace.bathspa.ac.uk/id/eprint/14461
Request a change to this item or report an issue Request a change to this item or report an issue
Update item (repository staff only) Update item (repository staff only)