The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations

Duffy, A, Vandeleur, C, Heffer, N ORCID: 0000-0002-6597-0134 and Preisig, M (2017) 'The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations.' International Journal of Bipolar Disorders, 5. art. 37.

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Abstract

Background:- Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajectory is key to risk prediction and early intervention advancement. Main body:- In this narrative review, we discuss key findings from prospective longitudinal studies of the high-risk offspring of bipolar parents and related meta-analyses that inform us about the clinical trajectory of emerging bipolar disorder. Challenges such as phenotypic and etiologic heterogeneity and the non-specificity of early symptoms and syndromes are highlighted. Implications of the findings for both research and clinical practice are discussed. Conclusion:- Bipolar disorder in young people at familial risk does not typically onset with a hypomanic or manic episode. Rather the first activated episode is often preceded by years of impairing psychopathological states that vary over development and across emerging bipolar subtype. Taking heterogeneity into account and adopting a more comprehensive approach to diagnosis seems necessary to advance earlier identification and our understanding of the onset of bipolar disorder.

Item Type:	Article
Keywords:	bipolar disorder, early course, antecedents, stages, illness trajectory, high-risk, offspring
Divisions:	School of Sciences
Date Deposited:	22 Feb 2022 20:21
Last Modified:	20 Dec 2023 05:30
ISSN:	2194-7511
URI / Page ID:	https://researchspace.bathspa.ac.uk/id/eprint/14577

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